Reliability prediction of the brake pads is indispensable to guarantee their safety. In the paper, the fatigue reliability of brake pads is analyzed by dynamic stress-strength interference (SSI) model considering strength degradation. Firstly, reliability model of the brake pads was established based on stress-strength interference model considering the influence of impact load. Then reliability of the brake pads was predicted under different impact load frequency and initial strength. Finally, the influence of random degradation strength on reliability was studied by contrast. The analysis results show that random strength degradation, impact load and initial strength have great influence on reliability prediction for the brake pads. Therefore, the reliability prediction of the brake pads fatigue strength considering strength degradation is more in line with the actual situation and the calculation accuracy is higher.